Say something if your friend is spending less and less time with you or making up excuses. She also does not call or email you although she has in the past. Or, on the flip side, she calls too much or at bad times for no reason such as when you are eating, late at night, studying or putting your children to bed.

Raise a red flag if you see negative comments on websites such as MySpace and Facebook posted by your friend or an alias she uses. If you confront her about it, she denies it or refuses to apologize.

Notice if she has begun only talking about herself and her own issues and does not give you a chance to speak. She demonstrates little regard for your feelings and life issues or concerns. She will only participate in activities or go places with you that she likes.

While she is still very nice in person, you suspect and even have proof that she is gossiping and slandering you to others and turning others against you.

Notice if she becomes very competitive, having to win everything and putting competitions in front of the friendship. She does this with little regard for your feelings.

Be aware if she assumes because she is your best friend, she has the right to borrow or use any property of yours at any time. This includes cell phones, electronics, clothes, jewelry or even borrowing money. Notice id she is often not nice about it, many times not even asking, just taking.

Step back if she takes advantage of the friendship by assuming you will care for her home, plants or pets while she is away. Or, she routinely backs you into babysitting for her children.